梁兴杰，男，生于1972年1月，河北省辛集市人。中国科学院生物物理研究所，生物大分子国家重点实验室膜分子生物学室获得博士学位 （1997-2000），美国国立卫生研究院 (NIH) 国家肿瘤研究所 (NCI) 细胞生物学实验室 (LCB) 博士后（2000-2005），美国国家神经疾病与中风研究所 (NINDS), 帕特神经科学研究中心(Porter Neuroscience
Research Center)研究人员（research
fellow）（2005-2007），Howard University医学院放射医疗系助理教授（2007-2010）。现为研究员，博士生导师, 国家杰出青年基金获得者(生物材料和纳米医学)，享受国务院特殊津贴。国家纳米科学中心纳米可控药物学实验室主任，中国科学院纳米生物效应与安全性重点实 验室副主任，《Biophysics
Reports》副主编， 《Current Nanoscience》,《Advanced in Nano Research》，《Journal of Nanomaterials》，《Theranostics》《Biomaterials Research》等杂志编委及《Biotechnology Advances》杂志客座编委。迄今为止，发表SCI收录论文168余篇；申请中国发明专利 26项。2004，2005，2006 连续三年获得NIH优秀科研奖（”Fellows Award for Research
Excellence”）。2010获得国务院政府有突出贡献专家(自然科学类)，2012年获得国家杰出青年基金（生物材料和纳米医学），2012年获 得中国药学会青年药物学家奖， 2014年获得国家质量监督检验检疫总局“科技兴检奖”。

联系方式：E-mail:
liangxj@nanoctr.cn

二、主讲课程及研究方向

1.主讲课程：纳米生物学，纳米医学
2.研究方向：纳米药物的设计合成、结构优化和功能测定及其临床应用中的生物机制。

三、代表性论文

1.    Xiaowei
Ma, Yuliang, Zhao, XingJie Liang*.
Theranostic Nanoparticles engineered for Clinic and Pharmaceutics. Accounts
Chem Res. 2011. 44(10): 1114–1122

2.    Xiangdong
Xue, Yuanyuan Zhao, Luru Dai, Xu Zhang, Xiaohong Hao, Shuaidong Huo, Juan Liu,
Chang Liu, Anil Kumar, Weiqing Chen, Guozhang Zou and Xingjie Liang*. Spatiotemporal Drug Release Visualized Through a
Drug Delivery System with Tunable Aggregation-Induced Emission. Adv Mater,
2014. 26(5):712-717.

3.    Tuo
Wei, Juan Liu, Huili Ma, Qiang Cheng, Yuanyu Huang, Jing Zhao, Shuaidong Huo,
Xiangdong Xue, Zicai Liang and Xingjie
Liang*. Functionalized nanoscale micelles improve the drug delivery for
cancer in vitro and in vivo. Nano Letter, 2013. 13(6):2528-2534.

4.    Xue
Xue, Li-Rong Wang, Yutaka Sato, Ying Jiang, Martin Berg, Dun-Sheng Yang, Ralph
A. Nixon and Xingjie Liang*.
Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in
primary glia from a mouse model of Alzheimer’s disease. Nano Lett. 2014
14(9):5110-5117.

5.   XingJie Liang*, Huan Meng, Yingze Wang,
Haiyong He, Jie Meng, Juan Lu, Paul C. Wang, Yuliang Zhao, Xueyun Gao, Baoyun
Sun, Chunying Chen, Genmei Xing, Dingwu Shen, Michael M. Gottesman, Yan Wu,
Junjie Yin, and Lee Jia. Metallofullerene Nanoparticles Circumvent Tumor
Resistance to Cisplatin by Reactivating Endocytosis. Proc Natl Acad Sci U S A.,
2010, 107(16):7449-7454.

6     Qiao
Jiang, Chen Song, Jeanette Nangreave, Xiaowei Liu, Lin Lin, Dengli Qiu,
Zhengang Wang, Guozhang Zou, Xingjie
Liang, Hao Yan, Baoquan Ding. DNA Origami as a Carrier for Circumvention of
Drug Resistance. JACS, 2012. 134 (32), pp 13396–13403.

7.    Shutao
Guo, Yuanyu Huang, Qiao Jiang, Yun Sun, Liandong Deng, Zicai Liang, Quan Du,
Jinfeng Xing, Yuliang Zhao, Paul C. Wang, Anjie Dong and XingJie Liang*. Enhanced Gene Delivery and siRNA Silencing by Gold
Nanoparticles Coated with Charge-reversal Polyelectrolyte. ACS Nano., 2010.
4(9): 5505-5511.

8.    Xiaowei
Ma, Yanyang Wu, Shubin Jin, Yuan Tian, Xiaoning Zhang, Yuliang Zhao, Li Yu* and Xingjie Liang*. Gold Nanoparticles
Induce Autophagosome Accumulation through Size-Dependent Nanoparticle Uptake
and Lysosome Impairment. ACS Nano., 2011. 5 (11): 8629–8639.

9.    Shuaidong
Huo, Shubin Jin, Xiaowei Ma, Xiangdong Xue, Keni Yang, Paul C. Wang, Jinchao
Zhang,  Zhongbo Hu and Xingjie Liang*. Ultra-small Gold
Nanoparticles as Carriers for Nucleus-based Gene Therapy Due to Size-dependent
Nuclear Entry. ACS nano. 2014. 24;8(6):5852-5862.

10.  Lu
Han, Jing Zhao, Xu Zhang, Weipeng Cao, Xixue Hu, Guozhang Zoua, Xianglin Duan
and Xingjie Liang*. Simple
charge-reversal polymer assembly nanosystem with good biocompatibility for
enhanced siRNA delivery and silencing. ACS Nano., 2012. 28; 6(8):7340-7351.

11.  Xue
Xue, Matthew Hall, Qiang Zhang, Paul Wang, Michael M Gotteman, Xingjie Liang*. Nanoscale Drug Delivery
Platforms Overcome Platinum-Based Resistance in Cancer Cells Due to Abnormal
Membrane Protein Trafficking. ACS Nano., 2013. 23;7(12):10452-10464.

12.  Keyang
Huang, Huili Ma, Juan Liu, Shuaidong Huo, Anil Kumar, Tuo Wei, Xu Zhang, Shubin
Jin, Yaling Gan, Paul C. Wang, Shengtai He, Xiaoning Zhang and Xingjie Liang*. Size-Dependent
Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells,
Multicellular Spheroids, and Tumors in vivo. ACS Nano. 2012. 6 (5), 4483–4493.

13.  Shuaidong
Huo, Huili Ma, Keyang Huang, Juan Liu, Tuo Wei, Shubin Jin, Jinchao Zhang,
Shengtai He and Xingjie Liang*.
Superior penetration and retention behavior of 50nm gold nanoparticles in
tumor. Cancer Research, 2013. 73:319-330.

14.  Juan
Liu, Yuran Huang, Anil Kumar, Aaron Tan, Shubin Jin, Anbu Mozhi, Xingjie Liang*. pH-Sensitive
nano-systems for drug delivery in cancer therapy. Biotechnol Adv, 2014.32(4):
693-710.

15.  Shutao
Guoa, Yuanyu Huang, Tuo Wei, Wendi Zhang, Weiwei Wang, Daoshu Lin, Xu Zhang,
Anil Kumar, Quan Du, Jinfeng Xing, Liandong Deng, Zicai Liang, Paul C. Wang,
Anjie Dong and XingJie Liang*.
Amphiphilic and Biodegradable Methoxy Polyethylene
glycol-block-(polycaprolactone-graft-poly (2-(dimethylamino)ethyl
methacrylate)) as an Effective Gene Carrier. Biomaterials, 2011, 32(3):
879-889.

16.  Xiaodong
Zhang, Di Wu, Xiu Shen, Jie Chen, Yuan-Ming Sun, Peixun Liu, Xingjie Liang*. Size-dependent
radiosensitization of PEG-coated gold nanoparticles for cancer radiation
therapy. Biomaterials, 2012. 33(27):6408-19.

17.  Anil
Kumar, Huli Ma, Xu Zhang, Keyang Huang, Shubin Jin, Juan Liu, Tuo Wei, Weipeng
Cao and Xingjie Liang*. Gold
nanoparticles functionalized with therapeutic and targeted peptides for cancer
treatment. Biomaterials, 2012. 33(4): 1180-1189.

18.  Lu
Hana, Jing Zhao, Juan Liu, Xianglin Duan, Luhai Li, Xianfu Wei, Yen Wei, Xingjie Liang*. A universal gene
carrier platform for treatment of human prostatic carcinoma by p53
transfection. Biomaterials, 2014 35(9):3110-3120.

19.  Deng
Hua, Xu Zhang, Guozang Zou, Anil Kumar, Xiaoning Zhang and Xingjie Liang*. Long genomic DNA amplicons adsorption onto
unmodified gold nanoparticles for colorimetric detection of Bacillus anthracis.
Chem Commun, 2013, 49(1):51-53.

20.  Juan
Liu, Huili Ma, Tuo Wei and Xinjie Liang*.
CO₂ gas induced drug release from pH-sensitive liposome to
circumvent doxorubicin resistant cells. Chem Commun, 2012, 48(40), 4869–4871.

21.  Hua
Deng, Yi Xu, Shuxian Shan, Yun Sun, Xiaofang Liu, Keyang Huang, Xiaowei Ma,
Guozang Zou, Zhijun Che, Yanhua Liu and Xingjie
Liang*. Gold nanoparticles with asymmetric polymerase chain reaction for
rapid colorimetric detection of DNA sequence. Anal Chem. 2012, 84 (3):
1253–1258.

22.  Hua
Deng, Yi Xu, Shuxian Shan, Yun Sun, Xiaofang Liu, Keyang Huang, Xiaowei Ma,
Guozang Zou, Zhijun Che, Yanhua Liu and Xingjie
Liang*. Gold nanoparticles with asymmetric polymerase chain reaction for
rapid colorimetric detection of DNA sequence. 2011. Anal Chem, 2012, 84 (3):
1253–1258.

23.  Feifei
An, Weipeng Cao and Xingjie Liang*.
Nanostructural Systems Developed with Positive Charge Generation to Drug
Delivery. Adv Healthc Mater, 2014 3(8): 1162-1181.

24.  Chunqiu
Zhang, Shubin Jin, Keni Yang, Xiangdong Xue, Zhipeng Li, Yonggang
Jiang,Wei-Qiang Chen, Luru Dai, Guozhang Zou*and Xingjie Liang*. Cell Membrane Tracker Based on Restriction of
Intramolecular Rotation. ACS Appl Mater Inter, 2014. 6(12):8971-8975.

25.  Chunqiu
Zhang, Shubin Jin, Shengliang Li, Xiangdong Xue, Juan Liu, Yuran Huang,
Yonggang Jiang, Weiqiang Chen, Guozhang Zou* and Xingjie Liang*. Imaging Intracellular Anti-Cancer Drug Delivery by
Self-Assembly Micelles with Aggregation-Induced Emission (AIE Micelles). ACS
Appl Mater Inter, 2014. 9;6(7):5212-5220.

26.  Chunqiu
Zhang, Chang Liu, Xiangdong Xue, Shuaidong Huo, Yonggang Jiang, Wei-Qiang Chen,
Guozhang Zou* and Xingjie Liang*.
Salt-Responsive Self-Assembly of Luminescent Hydrogel with Intrinsic
Gelation-Enhanced Emission. ACS Appl Mater Inter, 2014. 22;6(2):757-762.

四、科研项目
1. 科技部重大研究计划（973项目）纳米科学研究项目（项目批准号：2009CB930200，2009 -2013年，主持人）。

2. 科技部国家高技术发展技术（863）计划-生物和医药技术领域
（项目批准号：SS2014AA020708，2014 -2016年，主持人）。

3. 中国科学院“百人计划”人才基金项目 （项目批准号：07165111ZX，2008 -2011年，主持人）。

4. 国家自然科学基金委杰出青年基金项目 （项目批准号：31225009，2013 -2015年，主持人）。

五、授权专利

1.发明人：梁兴杰,
何海勇,
贲虎.
发明名称：一种氢氧化铝纳米带及其制备方法.
专利号：ZL200910242584.2

2.发明人：梁兴杰,
邓华,
马晓溦.
发明名称：一种核酸的检测方法和一种试剂盒及应用.
专利号：WO2012129821
A1

六：获奖情况

2014年获得国家质量监督检验检疫总局“科技兴检奖”

2013年获得中科院百人计划终期结题优秀奖 

2012年获得国家杰出青年基金

2012年获得中国药学会青年药剂学家奖

2010年国务院政府特殊津贴获得者